How might health deficits in cells scale up to become clinically visible?

Prof Kenneth Rockwood is Director of Geriatric Medicine Research at Dalhousie University, Canada and serves on the International Advisory Panel of Age and Ageing journald

A July Age and Ageing paper on frailty considered how subcellular damage might “scale up” to lead to clinically detectable deficits. In December, a paper from Biogerontology addressed how deficits originate, and how they might scale.  The proposed answer appears to be powerful and offers some insights into how to think about frailty and disease in older adults. Continue reading