Mary Ni Lochlainn is an Academic Clinical Fellow in Geriatric Medicine. She works at King’s College Hospital NHS Foundation Trust.
In the world of Alzheimer’s research we heard from Professor Michael Rowan, who focused on amyloid and ageing. Sleep and mood disorders can pre-date dementia diagnoses, and we see circadian rhythm disturbances in Alzheimer’s disease (AD). Is there a window of opportunity here for preventative interventions? Alzheimer’s is a disease of abnormal protein aggregation – both amyloid and tau. Protein clearance tends to happen at night. Can we draw connections here? Prof Rowan explained that a recent New England Journal of Medicine paper showed 30% of patients didn’t have any amyloid even though they had been diagnosed with AD and enrolled in a trial. So what does this mean? Do these patients have another dementia? It cannot be denied that a blood or cerebrospinal fluid test would be very helpful in this diagnostic process. Continue reading